Asthafen 1mg (Ketotifen)

Overview

Asthafen 1mg Tablet is a prescription medication that contains Ketotifen Fumarate, a potent dual-action antihistamine and mast cell stabilizer. This medication is primarily used for the prevention and long-term management of asthma and allergic conditions, such as allergic rhinitis and allergic conjunctivitis. Unlike rescue inhalers, which provide immediate relief from asthma attacks, Asthafen is designed for regular, daily use to help reduce the frequency and severity of asthma attacks while managing other allergic symptoms.

Mechanism of Action

Asthafen works through its active ingredient, Ketotifen, which has a dual mechanism of action:

Histamine Receptor Blockade

Ketotifen blocks H₁ histamine receptors, which are involved in allergic reactions. By blocking these receptors, Asthafen helps reduce symptoms like itching, swelling, and redness that occur during allergic responses.

Mast Cell Stabilization

Ketotifen also stabilizes mast cells, preventing them from releasing histamine and other inflammatory mediators. This action reduces inflammation in the airways, helping to prevent asthma attacks and allergic flare-ups.
Additionally, Ketotifen inhibits the action of leukotrienes, substances that contribute to inflammation and bronchoconstriction in the lungs, which are key factors in asthma.

Indications

Asthafen 1mg Tablet is indicated for:

• Asthma Management: It is used as a long-term treatment to reduce the frequency and severity of asthma attacks by preventing airway inflammation and bronchoconstriction.
• Allergic Rhinitis: Asthafen is effective in treating symptoms of allergic rhinitis, such as sneezing, nasal congestion, and itching.
• Allergic Conjunctivitis: It helps relieve symptoms of eye allergies, such as itching, redness, and watering of the eyes.
• Chronic Urticaria (Hives): Asthafen may be used to treat persistent itching and rash associated with chronic hives.
• Mast Cell Disorders: It can help manage symptoms related to conditions such as mastocytosis.

Dosage and Administration

Adults and Children (3 years and older)

The usual dosage is 1 mg twice daily, once in the morning and once in the evening, preferably with food.

Administration

The tablet should be swallowed whole with a glass of water. Do not chew or crush the tablet.

Duration

For optimal results, it is important to use Asthafen regularly, even if symptoms improve. Long-term use is generally recommended for effective asthma management.

Adjustment

The dosage may be adjusted by your healthcare provider depending on the severity of your symptoms and individual response to the medication.

Side Effects

Asthafen is generally well tolerated, but as with any medication, side effects can occur. Common side effects include:

• Drowsiness or Sedation: This is the most common side effect, but it usually decreases over time as your body adjusts to the medication.
• Dry Mouth: This can be alleviated by drinking water or sucking on sugar-free candy.
• Increased Appetite and Weight Gain: Some patients may experience an increase in appetite, leading to weight gain.
• Headache and Dizziness: These may occur, especially when first starting the medication.
• Gastrointestinal Discomfort: Nausea or stomach upset can occasionally occur.

Less common but more serious side effects may include:

• Severe Allergic Reactions: Symptoms may include rash, itching, swelling, or difficulty breathing.
• Seizures: Though rare, Ketotifen can sometimes cause seizures, particularly in patients with a history of epilepsy.
• Heart Palpitations: Some individuals may experience an irregular or rapid heartbeat.
• Liver Dysfunction: Symptoms may include jaundice (yellowing of the skin or eyes). If these symptoms occur, immediate medical attention is necessary.

Precautions and Contraindications

Hypersensitivity

Asthafen should not be used if you are allergic to Ketotifen or any of the tablet’s components.

Pregnancy and Breastfeeding

It is advisable to use Asthafen during pregnancy and breastfeeding only if clearly needed and prescribed by your healthcare provider.

Children under 3 years of age

The safety and effectiveness of Asthafen in children under 3 years have not been established.

Epilepsy or Seizure Disorders

Patients with a history of seizures should use Asthafen cautiously and under medical supervision.

Liver or Kidney Impairment

If you have liver or kidney problems, your healthcare provider may adjust your dosage or monitor you more closely during treatment.

Storage Instructions

• Temperature: Store the tablets at room temperature, away from moisture and heat.
• Packaging: Keep the container tightly closed to prevent contamination.
• Children: Keep out of the reach of children.
• Disposal: Do not flush medications down the toilet or pour them into a drain unless instructed by your healthcare provider.