Phenergan 10 Mg (Promethazine)

What is Phenergan 10 Mg (Promethazine)

Phenergan 10 Mg (Promethazine) is a trusted prescription antihistamine that helps with allergy relief, motion sickness, and nausea.

Suppose you are searching for anti-nausea medicine, motion sickness tablets, or a sedating antihistamine that can also calm queasiness from illness or specific treatments.

In that case, this is a common option doctors use. The Phenergan 10 mg strength gives dose flexibility, which can be helpful if you are sensitive to medication or need lighter symptom control.

What Phenergan 10 helps with

• Seasonal or year-round allergy symptoms like sneezing, a runny nose, and itchy or watery eyes
• Motion sickness prevention and treatment during travel by car, plane, or boat
• Nausea and vomiting relief in select situations, as directed by a healthcare professional
• Pre and post-operative sedation when recommended by your care team

How Phenergan works

Promethazine blocks histamine H1 receptors and also has anticholinergic properties. That combination reduces allergy symptoms and helps settle the stomach.

It is sedating, which can be helpful when you want to rest, but it also means you should be ready for drowsiness after taking it.

How to take Phenergan 10 Mg

Follow your prescriber’s instructions exactly. You can usually take promethazine with or without food. If it bothers your stomach, a light snack is fine. For motion sickness, your clinician may advise taking a dose before travel starts.

Do not take more than prescribed. If the 10 mg dose feels too strong or not strong enough, talk with your prescriber about adjusting the plan instead of changing it on your own.

What to expect

• Onset: Many people start to feel relief within an hour.
• Duration: Effects often last several hours. Drowsiness may linger, so plan your activities.
• Common effects: Sleepiness, dry mouth, dizziness, blurred vision, constipation.
• Less common but essential: Confusion, trouble breathing, severe sleepiness, or unusual movements. Get medical help if these occur.

Safety notes you should know

• Severe warning for young children: Promethazine should not be used in children under 2 years because of the risk of slowed or stopped breathing.
• Driving and machinery: Avoid until you know how you react. Many people feel quite drowsy.
• Alcohol and other sedatives: Combining with alcohol, opioids, benzodiazepines, sleep aids, or cannabis can increase sedation and breathing risk. Use only if your prescriber says it is safe.
• Medical conditions: Tell your clinician if you have glaucoma, breathing disorders like asthma or COPD, an enlarged prostate or urinary retention, sleep apnea, liver problems, or a history of seizures.
• Interactions: Let your prescriber know about antidepressants, MAO inhibitors, antipsychotics, anti-anxiety medicines, and any other antihistamines or anticholinergics you use. This helps avoid extra drowsiness or other side effects.
• Pregnancy and breastfeeding: Ask your obstetric or pediatric clinician before use. They will weigh risks and benefits for your situation.
• Sun sensitivity: Your skin may be more sensitive to sunlight. Consider sunscreen, sunglasses, and protective clothing when outdoors.

Simple tips

• Stay hydrated. Sips of water or ice chips can help if your mouth feels dry.
• Sugar-free gum or lozenges may ease dry mouth.
• Get up slowly from sitting or lying down to reduce dizziness.
• Keep a symptom diary if you are figuring out your best timing for motion sickness prevention.

Storage guide

Store tablets at room temperature in a dry place, away from direct heat and light. Keep the bottle tightly closed and out of reach of children and pets.

Who this strength may suit

The 10 mg tablet can be a good starting dose your clinician may use for lighter symptoms, for older adults who need a lower dose, or for people who are sensitive to sedating medicines.

If you need more substantial relief, your prescriber may adjust to a higher strength or a different schedule.

Available Strengths of Phenergan 

• Promethazine Cream
• Tablets: 10 mg, 12.5 mg, 25 mg, 50 mg
• Suppositories: 12.5 mg, 25 mg, 50 mg
• Oral syrup/solution: commonly 6.25 mg per 5 mL

Note: Availability can vary by manufacturer and pharmacy. Use only the form and strength your clinician prescribes.

FAQs About Phenergan 10 Mg

Can I split or crush Phenergan 10 mg tablets?

Some tablets can be split if they are scored, but not all are designed to be separated or crushed. Check the imprint and ask your pharmacist before altering a tablet. Crushing can change how it works or increase side effects.

How long does promethazine stay in my system?

You may feel relief for 4 to 6 hours, and drowsiness can last longer. The half-life is roughly 10 to 19 hours, meaning traces can persist into the next day. Plan your travel or activities with that in mind.

Can I take Phenergan with melatonin or other sleep aids?

Combining promethazine with melatonin or other sedatives can make you very sleepy and may not be safe for everyone. Check with your clinician first to avoid stacking sedatives.

Is Phenergan habit-forming?

It is not considered habit-forming in the way some anxiety or pain medicines are, but people can become reliant on the sedating effect for sleep. Use it only as prescribed, and do not take extra doses to help you sleep.

What should I do if I miss a dose?

If you are on a schedule and miss a dose, take it when you remember, unless it is close to the next dose. If it is almost time for the next one, skip the missed dose. Do not double up. For motion sickness or nausea, your prescriber may give you as-needed directions.